The non-contact cell disruptor is an automatic frequency tracking cell disruptor, also known as a cup disruptor, used for aseptic fragmentation. It can break chromosomes and cells through a centrifuge tube. Specially designed for the pre-treatment of second-generation sequencing DNA samples and chromatin immunoprecipitation experimental samples, compared to traditional probe contact ultrasonic cell disruptors, non-contact samples can be crushed in a sealed container without producing infectious flying mist. The ultrasonic probe does not come into contact with the sample to avoid cross contamination. The non-contact ultrasonic crusher can achieve unparalleled quality, efficiency, and safety compared to traditional ultrasonic methods.